featured
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Peeking at huntingtin and learning from a PET study
Scientists tested a new tool to measure harmful HTT protein in HD. It wasnāt perfect, but offered key insights to guide better tools already in the works. A big step toward tracking HD non-invasively, from inside the brain!
By Dr Leora Fox -
June 2025: This Month in Huntingtonās Disease Research
June was filled with exciting research! Ranging from clinical trial updates to irritability, we’ve rounded up the most exciting Huntington’s disease research from this month.
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Trouble on the Block: When the Neighborhood Loses Its Best Firefighter
In HD, a key brain protector, PKD1, is missing. Without this āmolecular firefighter,ā neurons are vulnerable. Knowing why it disappears may help us uncover how the brainās defense break down, and how to reinforce it.
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Spark ignited: first HD patient dosed in new Roche gene therapy trial
Spark and Roche issued a joint community letter to share that the first patient has been dosed in a new HD gene therapy trial.
By Dr Leora Fox -
When a Short Fuse Becomes a Storm: Understanding Irritability in Huntingtonās Disease
For people living with HD, irritability can erupt like a storm, sudden and overwhelming. In a new study, researchers spoke directly to people with HD to understand what irritability truly feels like.
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Inside the Brainās Theme Park: How Huntingtonās Disease Disrupts the Emotion Coaster
Welcome to Brainland, the bustling, 24/7 theme park in your head. Thereās Memory Maze, Logic Log Flume, and of course, the Emotion Coaster, where your brain races through tracks themed around happiness, sadness, and anger. However, for some people who carry the gene for Huntingtonās disease (HD), some of these rides start acting up long…
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One Disease, Many Paths: How Brain Wiring Shapes Huntingtonās Symptoms
HD starts with a single gene change, but its effects travel many roads. New work shows how brain networks breakdown or reroute. Whether movement, thinking, or mood are most affected, we may be able to guide care in a more personalized direction.
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Full Steam Ahead: uniQureās On Track With Hope for Accelerated Approval of Huntingtonās Disease Drug
uniQure has aligned with the US FDA on next steps to achieve accelerated approval of AMT-130. If data remain positive, they will be on track to market the first HD gene therapy.
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The 2025 HDBuzz Prize for Young Science Writers Is Open!
Announcing the 2025 HDBuzz Prize for Young Science Writers – sponsored by the Hereditary Disease Foundation!
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May 2025: This Month in Huntingtonās Disease Research
From vision changes to genetic traffic jams and a clinical trial update, May was full of HD science excitement! Dive into our latest roundup to see how researchers are advancing Huntingtonās disease in exciting new ways.