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HD2026 Milton Wexler Biennial Symposium Day 3
Day 3 of #HD2026 put HTT under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT might help. Read our roundup here.
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HD2026 Milton Wexler Biennial Symposium Day 2
ā±ļø 23 min read | Day 2 of #HD2026 brought us updates on the mechanics of somatic instability, new ways to track HD in people, AI tools to help drive research forward, and developments in our understanding of the HTT protein. Catch up right here.
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HD2026 Milton Wexler Biennial Symposium Day 1
ā±ļø 28 min read | Day 1 of HD2026 is a wrap! From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, todayās talks spanned the spectrum from fundamental biology to potential treatments.
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Prilenia shares HD trial data with CHDI to help future research
Clinical trial data can drive discovery long after a study ends. Prilenia donated placebo-arm data from 2 HD clinical trials to CHDI, a valuable resource for researchers to better understand placebo effects, HD progression and future trial design.
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Looking back and moving forward: Questions and lessons 4 weeks out from Rocheās disappointing news
ā±ļø10min read | Roche’s decision to stop development of 2 HTT-lowering programmes is disappointing, but the story doesn’t end there. Years of research answered some key questions, raised many new ones, and will inform the next generation of HD trials.
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July 2026: This Month in Huntington’s Disease Research
ā±ļø 8 min read | July was a hard month for Huntington’s disease research, with Roche ending two HD programs. But the month also brought promising new tools, a new player in somatic expansion, and important work on eating and self-awareness in HD.
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Putting it in print: a clinical trial trying to rein in runaway pruning
ā±ļø10 min read | Four years after announcing positive results in their trial of ANX005 (tanruprubart) for HD, Annexon has formally published the results. Itās safe, hits its target, and may have helped some participants ā so whatās the holdup?
By Dr Leora Fox -
Joining the Starting Lineup: MutLĪ²ās Role in DNA Repeat Expansions
ā±ļø8 min read | Scientists have known that MutLĪ² is linked to repeat expansion but not exactly how. A study reveals that the MutLĪ² protein complex is a main player supporting and interacting with key DNA repair proteins to drive DNA repeat expansions.
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Catching a Giant Protein: Five New Ways to Grab Huntingtin
ā±ļø8 min read | Scientists screened over a trillion tiny ring-shaped protein fragments to find ones that can grab onto the huntingtin. They captured huntingtin straight out of cells and discovered itās almost always paired with a partner called HAP40.
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Mirror, Mirror on the Wall: When Self-Awareness Shifts in Huntingtonās Disease
ā±ļø6 min read | A new study suggests that reduced awareness of symptoms, known as anosognosia, may appear even in the earliest stages of HD. The findings highlight that understanding symptom progression requires more than one perspective.